I once promoted a high-ticket product because the commission looked amazing. The problem was that my audience wasn't ready to spend that much money. I eventually switched to a lower-priced product that solved a more immediate problem. The commission was smaller, but I started seeing more consistent sales.
 
I'd look at EPC as well as the headline commission. A program paying $100 doesn't automatically have better economics if its conversion rate and earnings per click are poor.
 
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